Proper control of the temporal onset of cellular differentiation is critical for regulating cell lineage decisions and morphogenesis during development. Pbx homeodomain transcription factors have emerged as important regulators of cellular differentiation. We previously showed, by using antisense morpholino knockdown, that Pbx factors are needed for the timely activation of myocardial differentiation in zebrafish. In order to gain further insight into the roles of Pbx factors in heart development, we show here that zebrafish pbx4 mutant embryos exhibit delayed onset of myocardial differentiation, such as delayed activation of tnnt2a expression in early cardiomyocytes in the anterior lateral plate mesoderm. We also observe delayed myocardial morphogenesis and dysmorphic patterning of the ventricle and atrium, consistent with our previous Pbx knock-down studies. In addition, we find that pbx4 mutant larvae have aberrant outflow tracts and defective expression of the proepicardial marker tbx18. Finally, we present evidence for Pbx expression in cardiomyocyte precursors as well as heterogeneous Pbx expression among the pan-cytokeratin-expressing proepicardial cells near the developing ventricle. In summary, our data show that Pbx4 is required for the proper temporal activation of myocardial differentiation and establish a basis for studying additional roles of Pbx factors in heart development.
from #Medicine via ola Kala on Inoreader http://ift.tt/1LbRaD6
via IFTTT
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
►
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
-
▼
2015
(2119)
- ► Δεκεμβρίου (940)
-
▼
Νοεμβρίου
(765)
-
▼
Νοε 12
(48)
- OtoRhinoLaryngology & Medicine,New Articles,Novemb...
- Reply to the Letter “Effect of anti-oxidant agents...
- Age-related effects on verbal and visuospatial mem...
- Molecules, Vol. 20, Pages 20341-20354: Direct Amin...
- Molecules, Vol. 20, Pages 20334-20340: Triterpenoi...
- Molecules, Vol. 20, Pages 20320-20333: Enhancement...
- Molecules, Vol. 20, Pages 20312-20319: Cytotoxic A...
- Molecules, Vol. 20, Pages 20355-20380: α-Linolenic...
- IJMS, Vol. 16, Pages 27072-27086: A Comparative St...
- IJMS, Vol. 16, Pages 27058-27071: Benzene-Induced ...
- IJMS, Vol. 16, Pages 27044-27057: Online Measureme...
- A predictive coding account of MMN reduction in sc...
- Successful cutting balloon angioplasty in a child ...
- Development of repeatable arrays of proteins using...
- Materials, Vol. 8, Pages 7650-7662: High Temperatu...
- Microorganisms, Vol. 3, Pages 866-889: Hydrogen Su...
- Microorganisms, Vol. 3, Pages 851-865: Bioactiviti...
- Molecules, Vol. 20, Pages 20297-20311: Derinat Pro...
- Materials, Vol. 8, Pages 7663-7672: Enhanced Erbiu...
- Prenatal diagnosis of single gene disorders using ...
- Identification of biomarkers to measure HIV-specif...
- Dynamics and role of antibodies to Plasmodium falc...
- Metals, Vol. 5, Pages 2119-2127: Liquid Phase Sepa...
- Metals, Vol. 5, Pages 2109-2118: Dynamic Strain Ev...
- Life, Vol. 5, Pages 1610-1628: Non-Standard Geneti...
- Life, Vol. 5, Pages 1587-1609: Starvation-Survival...
- Laws, Vol. 4, Pages 709-728: The Convention for th...
- Molecules, Vol. 20, Pages 20286-20296: β–Cyclodext...
- Effect of anti-oxidant agents in patients with hep...
- Healthcare, Vol. 3, Pages 1158-1173: The Applicati...
- Games, Vol. 6, Pages 604-636: The Role of Implicit...
- Entropy, Vol. 17, Pages 7680-7697: Using Expectati...
- Forests, Vol. 6, Pages 4088-4104: Characterization...
- Coatings, Vol. 5, Pages 830-864: The Search for Du...
- Coatings, Vol. 5, Pages 816-829: Natural Deposit C...
- Catalysts, Vol. 5, Pages 1928-1947: Molybdenum (VI...
- Catalysts, Vol. 5, Pages 1911-1927: Zr-SBA-15 Lewi...
- Catalysts, Vol. 5, Pages 1897-1910: Direct Convers...
- Biomolecules, Vol. 5, Pages 3142-3176: Immune Mech...
- Microarrays, Vol. 4, Pages 551-569: SNPs Array Kar...
- Applied Sciences, Vol. 5, Pages 1134-1163: An Effi...
- JDB, Vol. 3, Pages 93-111: Pbx4 is Required for th...
- Reproductive history and risk of cognitive impairm...
- Toxins, Vol. 7, Pages 4706-4729: Metabolism of Deo...
- Reasons & Symptoms of Dengue Fever
- Intra-individual lap time variation of the 400-m w...
- IJMS, Vol. 16, Pages 27032-27043: A PPO Promoter f...
- IJMS, Vol. 16, Pages 27015-27031: Sildenafil Prote...
-
▼
Νοε 12
(48)
Αναζήτηση αυτού του ιστολογίου
Πέμπτη 12 Νοεμβρίου 2015
JDB, Vol. 3, Pages 93-111: Pbx4 is Required for the Temporal Onset of Zebrafish Myocardial Differentiation
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.