Publication date: Available online 23 October 2015
Source:Bioorganic & Medicinal Chemistry
Author(s): Gang Wang, Yutao Wang, Lei Wang, Leiqiang Han, Xuben Hou, Huansheng Fu, Hao Fang
Anti-apoptotic B-cell lymphoma-2 (Bcl-2) proteins are promising targets for cancer therapy. In the present study, a series of imidazolidine-2,4-dione derivatives were designed and synthesized to test their inhibitory activities against anti-apoptotic Bcl-2 proteins. Among them, compound 8k had better growth inhibitory effects on K562 and PC-3 cell lines compared to lead compound WL-276.
Graphical abstract
from #Medicine via ola Kala on Inoreader http://ift.tt/1PNpLhv
via IFTTT
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.