The Lupus Susceptibility Locus Sgp3 Encodes the Suppressor of Endogenous Retrovirus Expression SNERV

Treger et al. identify Snerv as the genes, encoding Krüppel-associated box zinc-finger proteins (KRAB-ZFPs), that underlie the Sgp3 and Gv1 lupus-susceptibility loci in mice. SNERV represses expression of non-ecotropic endogenous retroviruses (ERVs). Elevated ERVs in lupus patients correlate with KRAB-ZFP down-regulation, suggesting a central role for dysfunctional ERV regulation in human lupus.

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