An Antigenic Atlas of HIV-1 Escape from Broadly Neutralizing Antibodies Distinguishes Functional and Structural Epitopes

Dingens et al. mapped all possible single amino acid viral-escape mutations for a panel of HIV-1 broadly neutralizing antibodies that target major sites of vulnerability of HIV Env. This mutation-level antigenic atlas provides a comprehensive dataset for understanding viral immune escape and refining antibody-based immunotherapies and vaccines.

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