Time versus treatment: interpreting longitudinal data analysis of treprostinil

In a longitudinal analysis of observational data, Lawrence et al evaluated neonates with congenital diaphragmatic hernia (CDH) who received treprostinil for the treatment of pulmonary hypertension.1 Pulmonary hypertension drives CDH-related mortality,2 and careful study of therapeutic advancements is critical. However, this analysis may lead clinicians to adopt treprostinil before its risks and benefits have been delineated. We believe that several factors preclude the interpretation in the title that treprostinil improves persistent pulmonary hypertension associated with CDH.

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