Mechanistic modelling of Radium-223 treatment of bone metastases

Despite the reported effectiveness of 223RaCl2 for treatment of bone metastases, many questions remain regarding its dosimetry and pharmacodynamics. This study models three different 223RaCl2 uptake scenarios, comparing their predictions of time to first symptomatic skeletal event to published clinical data. Our results suggest that approaches which assume a uniform biodistribution of 223Ra throughout metastatic sites do not accurately predict biological effects of α-radionuclide therapies, with exposure of small sub-populations providing superior agreement with clinical data.

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