Does Adult Neurogenesis Persist in the Human Hippocampus?

Whether new neurons are added to the human brain in childhood or adulthood is of widespread interest. Our recent observations suggest that newborn neurons in the adult human hippocampus (HP) are absent or very rare (Sorrells et al., 2018). A subsequent study proposes that large numbers of new neurons continue to be produced in the adult human HP (Boldrini et al., 2018). This has stimulated discussion and re-appraisal of this topic. Human studies have intractable caveats, making it important to interpret both positive and negative observations, including our own work, with a critical lens.

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