Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis

Cai et al. report that Tet2-deficient hematopoietic stem and progenitor cells manifest a hyperactive IL-6/Shp2/Stat3/Morrbid pathway, which promotes cell survival under basal conditions and in response to inflammatory stress. Blocking this pathway using anti-inflammatory drugs (E3330 and SHP099) or by genetic loss of Morrbid mitigates this response.

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