Considerations for Assessing the Extent of Hippocampal Neurogenesis in the Adult and Aging Human Brain

Adult hippocampal neurogenesis (AHN) is implicated in brain adaptations and disease pathogenesis. A seminal study showed adult-born neurons in the subgranular zone (SGZ) of the dentate gyrus (DG) in cancer patients 58–72 years of age, detecting bromodeoxyuridine co-localization with neuronal markers (Eriksson et al., 1998). Subsequently, human AHN was reported using immunohistochemistry targeting markers expressed by neuronal cells at different maturational stages, in situ hybridization (ISH), and 14C decay-defined neuronal age (Spalding et al., 2013).

https://ift.tt/2BWe1sV