Regeneration after radiation- and immune-mediated tissue injury is not enhanced by type III interferon signaling

Type III interferons (IFN-III) modulate the homeostasis of epithelial cells and help to clear mucosal viral infections. We analyzed the role of the IFN-III pathway in (1) radiation induced thymus injury and (2) graft-versus-host disease after total body irradiation (TBI) and allogeneic hematopoietic stem cell transplantation (allo-HSCT), conditions which involve epithelial damage and cause patient morbidity. IFN-III did not significantly alter thymus regeneration after irradiation and did not affect GVHD after TBI and allo-HSCT.

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