Hepatocyte Transplantation: Quo Vadis?

Orthotopic liver transplantation (OLT) has been effective in managing end-stage liver disease since the advent of Cyclosporine immunosuppression therapy in 1980. The major limitations of OLT are organ supply, monetary cost and burden of lifelong immunosuppression. Hepatocyte transplantation (HT), as a substitute for OLT, has been an exciting topic of investigation for several decades. HT is potentially minimally invasive, and can also serve as a vehicle for delivery of personalized medicine through autologous cell transplant after modification ex vivo.

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