Multifocal Visual Evoked Potentials and Contrast Sensitivity Correlate with Ganglion Cell-Inner Plexiform Layer Thickness in Multiple Sclerosis

Neurodegeneration is an important component of the pathological process in multiple sclerosis (MS), a chronic disease of the central nervous system (CNS). The anterior visual pathway, a small compartment within the CNS, is a prominent site of demyelination and neurodegenerative damage and serves as a good model in MS (Pisa et al., 2017, Toosy et al., 2017). It is well known that within the first 3 to 6 months following acute optic neuritis (ON), significant axonal and neuronal loss occurs (Costello et al., 2008, Syc et al., 2012), resulting in permanent visual dysfunction.

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