Does the Addition of Vasopressin to Catecholamine Vasopressors Affect Outcomes in Patients With Distributive Shock?

The search identified 1,210 unique citations, with 23 randomized trials, totaling 3,088 patients, included in the review. Twenty-one studies enrolled patients with septic shock, one study enrolled post–cardiac surgery patients, and one study included both patient types. There were no studies of patients with anaphylaxis or neurogenic shock. Vasopressin was studied in 13 trials, and terlipressin (8 trials) was the most commonly studied analogue. Most trial protocols did not require that vasopressin be used with other vasopressors but allowed the addition of catecholamines if needed.

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