Abstract
Classical Hodgkin lymphoma (CHL) is characterized by an inflammatory background and Hodgkin/Reed‐Sternberg (HRS) cells. The HRS cells exhibit abundant amphophilic cytoplasm, large nuclei, vesicular chromatin and prominent inclusion like nucleoli. Disorders other than CHL may contain HRS – like cells. The HRS cells express CD30 in 90‐96% and CD15 in 75 – 85% of the cases. Pan B cell markers are expressed variably, the most consistent being PAX5.1 The variability in the morphology and immunophenotype poses diagnostic difficulty and other disorders may be mistaken for CHL.
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