Molecular engineering of nonaqueous, soft, and supramolecular biomaterials that lack vapor pressure can give rise to systems with novel structures, tunable properties, and useful mechanical behavior. This review highlights the development of exciting macromolecule‐, drug‐, and nanoparticle‐structured oleogels and explore their potential application in parenteral drug delivery.
Abstract
The engineering advantages of soft, nonaqueous, solvent‐free supramolecular materials have resulted in their emerging transition and adoption from a predominantly food, cosmetics, and paint industry‐driven technology to biocompatible matrices for parenteral drug delivery. Factors that have contributed to this trend are the drastic increase of hydrophobic and combination drugs in the pharmaceutical pipeline and the limitations of hydrated drug delivery materials with regard to poorly soluble drugs and biologics. This review highlights examples of nonaqueous, soft supramolecular materials, illustrates molecular engineering principles that may give rise to novel structures and unique properties, and explores emerging opportunities of application of these materials in parenteral drug delivery.
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