Biphasic pathologic pattern in transformed mycosis fungoides not associated with DUSP22‐IRF4 translocation

Abstract

Large‐cell transformation in mycosis fungoides (MF) is usually encountered in tumors and is associated with prognosis worsening. It is defined by the onset of more than 25% of lymphocytes, usually expressing CD30, exceeding 4 times the size of normal lymphocytes, either diffuse or organized in sheets in the dermal infiltrate. Recently, an unusual biphasic pathologic pattern was reported in lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large cell lymphoma (ALCL) which was constantly associated with DUSP22‐IRF4 gene rearrangement ^(1)(2)(3) . We report a case of transformed mycosis fungoides (TMF) with a biphasic infiltrate not associated with DUSP22 gene rearrangement.

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