Evaluation of 0.2% delmopinol mouth rinse for prevention of peri‐implant mucositis and peri‐implantitis: A randomized controlled canine study

Abstract

Objectives

To evaluate the effectiveness of 0.2% delmopinol mouth rinse in maintenance of peri‐implant tissue health and prevention or inhibition of peri‐implant mucositis and peri‐implantitis.

Materials and Methods

Four weeks following tooth extraction, eight titanium dental implants, were placed in six dogs' mandibles. Three dogs were assigned to the test or placebo mouth rinse. Eight weeks following implant installation (T2) ligature was placed to induce peri‐implant disease. Clinical and radiographic assessment was performed during the study period as well as micro‐CT analysis and histologic assessment to evaluate Bone‐Implant Contact at the end of the follow‐up (T4).

Results

Plaque at implant sites before ligature placement (T2) was lower for the test group (0.7 ± 1.0 vs 1.5 ± 1.3, P < .05). The ratio of affected implant (PD ≧4 mm) at T2 and T4 in the test group was significantly smaller than that of the placebo group (T2, 17% vs 47%, P < .01; T4, 67% vs 83%, P < .05). The test agent also seemed to be effective in partially preventing bone loss induced by ligature placement according to the Computed Tomography and histologic analysis (test, 1.1 ± 0.8 mm; placebo, 1.5 ± 0.9 mm).

Conclusions

Within the limits of this animal model study, the results of the study indicate that the 0.2% delmopinol rinse might play a role in prevention of peri‐implant disease development.

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