DEPDC1 predicts prognosis of hepatocellular carcinoma patients and regulates tumor proliferation and metastasis

Abstract

DEP domain containing 1 (DEPDC1) protein is a novel oncoantigen up‐regulated in multi‐type of cancers which presents oncogenic activity and high immunogenicity. However, the functional discovery and therapeutic potential of DEPDC1 in hepatocellular carcinoma (HCC) remain unclear. In this study, we demonstrated that DEPDC1 was frequently up‐regulated in HCC and associated with cancer diagnosis and poor prognosis for HCC patients. Moreover, DEPDC1 promotes HCC cell proliferation in vitro as well as carcinogenesis in vivo. Notably, DEPDC1 overexpression also increases the neoplasm metastasis ability of HCC cells both in vivo and vitro. Gene Set Enrichment Analysis (GSEA) results showed that the DEPDC1 expression is positive correlated with K‐RAS signal pathway, pathways in cancer and WNT/β catenin signal pathway, all of which are closely associated with specific cancer‐related gene sets. Our study provides the basis for further investigation of the molecular mechanism by which DEPDC1 promotes the development and metastasis of HCC.

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