High-dosage cefazolin achieves sufficient cerebrospinal diffusion to treat an external ventricular drainage-related Staphylococcus aureus ventriculitis. [Pharmacology]

A patient received continuous infusion of cefazolin 10 g then 8 g daily for an external ventricular drainage-related methicillin susceptible Staphylococcus aureus (MSSA) ventriculitis.

Median free concentrations in the cerebrospinal fluid were 11.9 mg/L and 6.1 mg/L after a 10-g and an 8-g dosage respectively. Free concentrations in the cerebrospinal fluid were always above MIC usually displayed by MSSA.

These results support the use of high dose cefazolin to achieve sufficient meningeal concentrations.

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