Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions

Li et al. utilize haploid ESCs to overcome the uniparental reproductive barriers in mice. They found parent-specific erasure of DNA methylation between parthenogenetic and androgenetic haploid ESCs. After combining gametes and hypomethylated haploid ESCs with certain imprinted region deletions, the authors generated normally growing bimaternal mice and live bipaternal mice.

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