The Use of N-of-1 Trials to Individualize Treatment in Patients With Renal Magnesium Wasting

Patients with chronic renal magnesium wasting often experience fatigue and neuromuscular symptoms. Most patients require lifelong treatment with high doses of magnesium salts. However, sufficient magnesium replenishment is difficult because high doses of magnesium salts induce diarrhea and other gastrointestinal symptoms. Another difficulty in treating hypomagnesemia is the lack of randomized controlled trials (RCTs) comparing different magnesium salts.1,2

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