An Anti-Tumor Immune Response is Evoked By Partial-Volume Single Dose Radiation in Two Murine Models

The response of tumors subjected to partial irradiation was studied in two different immunocompetent models. A single dose of 10-20Gy of radiation delivered to half the tumor, reproducibly activates an anti-tumor immune response that eliminates the entire tumor. This response is dependent on vascular adhesion molecules that mediate infiltration of cytotoxic T cells.

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