Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate

Using a highly efficient reprogramming system, Sardina et al. examined the dynamics of DNA methylation and hydroxymethylation. They found that throughout the process several transcription factors can recruit Tet2 to specific sites, leading to demethylation. Some of these sites became demethylated before chromatin opening.

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