Not to Treat

Pineal tumors of intermediate differentiation are pineal parenchymal tumors that appear histologically more aggressive than World Health Organization grade I pineocytomas. The prognosis of pineal tumors of intermediate differentiation is actually similar to that of pineocytomas in the setting of gross total resection (GTR), though they do have a higher rate of both local recurrence and leptomeningeal dissemination than lower-grade tumors. Given their rarity and the retrospective nature of the reports, the literature is limited to inform clinical management.

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