The impact of radiation therapy on lymphocyte count and survival in metastatic cancer patients receiving PD-1 immune checkpoint inhibitors

The impact of radiation therapy on circulating lymphocyte count and survival in metastatic cancer patients receiving immune checkpoint inhibitors (ICI) is unknown. In this retrospective review of 110 patients with metastatic NSCLC, melanoma, or RCC who received RT and PD-1 inhibitors, patients treated with >5 fractions of extracranial RT were more likely to experience severe lymphopenia (<500 cells/mL). Severe lymphopenia at the time of ICI initiation was independently associated with survival.

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