Secondary hypokalemic periodic paralysis as a rare clinical presentation of Conn syndrome

Hypokalemic periodic paralysis (hypoPP) is characterized by episodes of sudden-onset muscle weakness associated with low plasma potassium (<3,5 mmol/l). Since the generalized or focal muscle weakness in hypoPP lasts from a few minutes to several days, diagnostic delay is common and affected patients often receive a diagnosis of functional disorder. Primary hypoPP are a group of hereditary skeletal muscle channelopathies, usually with infantile or juvenile onset of symptoms, that are caused by mutations in CACNA1S or SCN4A genes (Statland and Barohn, 2013) eventually determining an altered muscle excitability and electromechanical coupling.

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