Radiation but With Delayed Reconstruction

The Danish 82b trial revealed significant benefits from postmastectomy radiation therapy (PMRT) among premenopausal women, including a survival benefit in even a subset enrolled with node-negative disease (1). Although risks of locoregional recurrence in modern US series of patients with T3N0 disease have been modest, some women may harbor occult residual disease in areas like the internal mammary region that might never yield clinically appreciable locoregional recurrence but nevertheless serve as a nidus for distant metastases.

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