Late Effects of Radiation Prime the Brain Microenvironment for Accelerated Tumor Growth

For many years, research on recurrent glioblastoma has largely focused on therapyinduced immediate radiobiologic changes to the tumor and surrounding tissues. In this study, we demonstrate that substantially delayed effects of irradiation on the brain microenvironment lead to a remarkable pattern of aggressive tumor regrowth. This affords new insights into the highly aggressive tumor regrowth pattern observed following radiotherapy and provides an avenue for determining the cellular basis for the aggressiveness of recurrent GBM.

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