Haplodeletion of Follistatin-like 1 Attenuates Radiation-induced Pulmonary Fibrosis in Mice

Radiation-induced pulmonary fibrosis (RIPF) is a complex pathophysiologic process and its mechanisms are poorly understood. This study investigated the role of Follistatin-like 1 (Fstl1) in RIPF. The findings confirmed the increased Fstl1 levels in serum and lung from patients with RIPF and animal models. Haploinsufficiency of Fstl1 attenuated radiation-induced lung fibrosis without affecting inflammatory response. The X-ray induced α-SMA expression and type I collagen deposit were decreased in Fstl1+/– lung fibroblasts.

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