Pioneering of Enhancer Landscapes during Pluripotent State Transitions

The transitions between different pluripotency states are regulated by large changes in enhancer landscapes. Two publications in this issue of Cell Stem Cell suggest that the pioneering and subsequent activation of silent enhancers by transcription factors (i.e., ESRRB and GRHL2) is a crucial event during these transitions (Adachi et al., 2018; Chen et al., 2018).

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