Short Hypofractionated Radiotherapy in Palliation of Pediatric Malignancies: Outcomes and Toxicities

This study analyzed outcomes in 62 pediatric patients who were treated with a total of 104 courses of short hypofractionated radiotherapy to the sites of recurrent or metastatic disease. Hypofractionation to a median cumulative biologically effective dose (BED10) of 43 Gy produced robust short-term local control and resulted in favorable treatment response and toxicities. Nevertheless, survival outcomes remained dismal. Large-scale prospective studies are required to identify optimal dose schemes for palliation of incurable childhood tumors.

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