Comparative hypolipidaemic effects of crude seed powder, aqueous and methanolic seed extracts of Buchholzia coriacea in carbon tetrachloride-induced toxicity in albino rats ( Rattus norvegicus )

Abstract

Comparative hypolipidaemic effects of aqueous seed extracts, methanolic seed extracts and crude seed powder of Buchholzia coriacea in rats intoxicated with carbon tetrachloride were evaluated for 56 days. A total of male albino rats (150–200 g) comprising of 12 normal and 132 CCl₄-induced toxic rats were divided into 4 major groups: control groups (normal, positive and negative controls) and 3 treatment groups (B. coriacea aqueous extract (BCAE) group, B. coriacea methanolic extract (BCME) group and B. coriacea crude powder (BCCP) group) of 36 albino rats. The major group was split into three sub-groups consisting of three replicates of four rats each. The normal, negative and positive control groups were given 1 ml/kg distilled water, 150 mg/kg of CCl₄ and 200 mg/kg of silymarin respectively, while each treatment group was administered 200, 400 and 800 mg/kg respectively. Serum samples were collected from selected rats in each replicate of both treatment and control groups after 7 days of intoxication and at 2 weeks interval for various lipid profile parameters using standard methods. A time-independent significant decrease (p < 0.05) was observed in total cholesterol; LDL-cholesterol, triglycerides, VLDL-cholesterol and significant increase (P < 0.05) in HDL-cholesterol were observed in hepatotoxic rats treated with the BCCP, BCAE and BCME in comparison with the control groups. Conclusively, post treatment with aqueous seed extracts, methanolic seed extracts and crude seed powder of B. coriacea significantly attenuated hyperlipidaemic activities. Therefore, it can be suggested that B. coriacea extracts could have a protective effects against cardiovascular diseases.

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