Endothelial Regeneration of Large Vessels Is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities

Quiescent endothelial cells are able to mount a robust mitotic response even in the presence of pulsatile and high-velocity blood flow. McDonald et al. showed that regeneration of aortic inner lining involves a subset of cells with hidden proliferative capacity that undergo rapid and significant transcriptional changes.

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