Comparative effectiveness of prostate cancer treatment options: limitations of retrospective analysis of cancer registry data

Using a unique population-based dataset that includes detailed data on comorbidities and functional limitations, we compared overall survival among the "healthiest" patients with localized prostate cancer who received different treatments. Survival results differed dramatically across groups, suggesting that despite the detailed health status data, residual confounding remained. This study highlights an important limitation of studies using population-based cancer registry data, especially when comparing survival outcomes of vastly different treatment modalities.

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