Relation between memory impairment and the fornix injury in patients with mild traumatic brain injury; a diffusion tensor tractography study

Objective We investigated the relation between memory impairment and the fornix injury in patients with mild traumatic brain injury(TBI), using diffusion tensor tractography(DTT). Design Eighty six chronic patients with mild TBI and 50 normal control subjects were recruited. Fractional anisotropy(FA) and fiber volume were measured for each reconstructed fornix. The patients were classified according to three types; type A(47 patients) - intact integrity of both fornical crura, type B(27 patients) - showed a discontinuation in either fornical crus, and type C(12 patients) - discontinuations in both fornical crura.The Memory Assessment Scale(MAS) was used for evaluation of memory function. Results FA and fiber volume showed weak positive correlations with global memory of MAS, respectively(r=0.303, P=0.006, r=0.271, P=0.014). Significant difference in the global memory of MAS was observed between type A and B, and between type A and C without difference between type B and C(p

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