In Reply to Yildirim and Topkan

We would like to thank Dr Yildirim et al for their interest in the Multi-Institution Reirradiation analysis addressing patient selection for reirradiation (1). The 2 questions are insightful and appropriate. First, how does tumor volume (GTV) factor into this conundrum and, second, what is the role of human papilloma virus (HPV) in outcomes after retreatment?

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