P27. The fasting hormone FGF21-an alternative therapy for Alzheimer’s disease?

Lipolysis is regulated by PPAR and its target genes apoE and ABCA1, which not only control the transport of cholesterol but also the proteolytic degradation of A-peptide (A plaques, which are found to be deposited in increased number in Alzheimer's disease (AD). Accordingly, it was shown that PPAR-activation stimulates A-degradation, in an ABCA1- and apoE-dependent manner. Thus, it is reasonable to assume that increased lipolysis may be neuroprotective and could in part minimize the risk of developing dementia.

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