Mapping Active Gene-Regulatory Regions in Human Repopulating Long-Term HSCs

Assessing the gene-regulatory landscape in HSCs is limited by immunophenotypical definition. Glimm and colleagues use γRV ISs to map >3,000 active enhancers and promoters in functionally defined human HSCs and use this data to identify miR-10a and miR-335 as regulators of early hematopoiesis.

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