Acquired and Inherited Bone Marrow Failure Syndromes

Acquired aplastic anemia (AA) and inherited bone marrow failure syndromes (IBMFS) are rare disorders characterized by the failure of production of mature erythrocytes, leukocytes, and platelets by the bone marrow. Pancytopenia is the usual presentation of acquired AA, while the inherited diseases may predominantly affect one or more lineages and variably evolve into broad hematopoietic failure. AA has usually been considered a consequence of an abnormal immune response to infectious or toxic agents such as drugs or chemicals.

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