Telocytes as possible precursors of PDGFRA-mutant gastrointestinal mesenchymal tumors—reply

We are pleased that Ricci et al. have provided supporting evidence for our hypothesis that the telocyte, the only CD34- and PDGFRA-positive cell of the stomach and intestines [1], is the cell of origin of inflammatory fibroid polyps (IFPs). IFPs arising sporadically or syndromically predominantly have a gain-of-function mutation within the PDGFRA gene and are CD34 and PDGFRA positive.

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