Early changes in serial CBCT-measured parotid gland biomarkers predict chronic xerostomia after head and neck radiotherapy

Imaging for head and neck radiotherapy (HNR) normal tissue treatment response typically requires advanced techniques and/or extra sessions, limiting wide adoption and clinical utility. Parotid glands were delineated on daily CBCT images during the course of HNR for 105 patients who had xerostomia grade scored at one year following treatment. CBCT-measured dynamic intensity changes were associated with chronic xerostomia, with improved prediction over dose alone, which may have profound implications for adaptive radiotherapy.

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