Single Dose Daily Fractionated Is Not Inferior To Twice A Day Fractionated Total Body Irradiation Prior To Allogeneic Stem Cell Transplantation For Acute Leukemia: A Useful Practice Simplification Resulting From The Sarasin Study

Fractionated total body-irradiation (FTBI) delivering 12Gy in 6 fractions is considered as the standard schedule prior to transplant. For radiotherapy department organization, twice-daily FTBI schedule is a highly time-consuming and agenda disrupting technique. One option to increase TBI offer is to use only one fraction/day. Our report demonstrate that 12Gy-FTBI can be delivered safely in terms of disease control and survival following a single dose of 3 or 4Gy per day. This is of considerable practical importance for radiotherapy centers organization. Further analyses regarding non-lethal acute and late toxicities are planned.

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