Mutations in gyrA and gyrB in Moxifloxacin-Resistant Mycobacterium avium Complex and Mycobacterium abscessus Complex Clinical Isolates [PublishAheadOfPrint]

Data are limited on the frequency of gyrA and gyrB mutations in fluoroquinolone-resistant isolates of the Mycobacterium avium complex (MAC) and M. abscessus complex (MABC). In our analysis, we did not find any resistance-associated mutations in gyrA or gyrB in 105 clinical isolates of MAC or MABC, including 72 moxifloxacin-resistant isolates. Our findings suggest that mechanisms other than gyrA and gyrB mutations contribute to moxifloxacin resistance in these organisms.

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