Objective Predictors of 'Early Tolerance' to Ventral Intermediate Nucleus of Thalamus Deep Brain Stimulation in Essential Tremor Patients

Essential tremor (ET), is the most common cause of adult onset tremors. The diagnosis is made clinically on the basis of chronic, disabling action tremors. The phenotype is variable and heterogeneous; some patients experience a gradual increase in severity and disability over the years, others developed generalized tremors, including legs, head, and voice; and some individuals evolve into a pancerebellar syndrome that includes limb dysmetria and gait ataxia. In accordance with the varied clinical presentation, the tremor may be generated by different pathophysiologic mechanisms, with important therapeutic and prognostic implications(Louis et al.

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