Findings on Surveillance Imaging after Pre-operative Partial Breast Irradiation for Early Stage Breast Cancer

This retrospective study evaluated mammographic findings after pre-operative accelerated partial breast irradiation delivered via stereotactic body radiotherapy (SBRT) or a conventionally-fractionated regimen. High-dose SBRT, in particular, increases the risk of developing a uniquely robust and well-demarcated pattern of fat necrosis on mammogram. However, a higher rate of vigorous fat necrosis was also seen in the conventionally fractionated pre-operative PBI patients. This may reflect the less extreme but still hypofractioned schedule and/or the interaction of surgical resection with an irradiated tissue bed.

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