The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension

Congenital diaphragmatic hernia (CDH) is a complex syndrome that causes severe hypoxemic respiratory failure and is associated with high mortality. CDH is characterized by varying degrees of pulmonary hypoplasia and pulmonary vascular disease because of structural and functional pulmonary vascular abnormalities, often leading to pulmonary hypertension (PH). The impact of pulmonary vascular disease starts in utero and in concert with these changes, fetal circulatory changes and LV hypoplasia contribute to neonatal systolic and diastolic cardiac dysfunction in CDH after birth.

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