Human hematopoietic stem cells (HSCs) display substantial transcriptional diversity during development. Here, we investigated the contribution of alternative splicing to such diversity by analyzing the dynamics of a key hematopoietic regulator, HMGA2. Next, we showed that CLK3, by regulating the splicing pattern of HMGA2, reinforces an HSC-specific program.
https://ift.tt/2IuI1we
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
▼
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
-
▼
Απριλίου
(5349)
-
▼
Απρ 05
(179)
- A Multi-Institutional Validation of Gleason Score ...
- Outcome of Pancreaticoduodenectomy at Low-Volume C...
- Managing Gait, Balance, and Posture in Parkinson’s...
- Atezolizumab in Metastatic Urothelial Carcinoma Ou...
- Targeting the human epidermal growth factor recept...
- Major Determinants of Nucleosome Positioning
- Routine histopathological examination after female...
- Population‐based study of the sensitivity of axill...
- Influence of Stem Cell Therapy on Thyroid Function...
- The Effects of Injected Vitamin D on Prognosis of ...
- A Meta-Analysis of the Associations Between the AT...
- Cushing’s Syndrome: A Historic Review of the Treat...
- ACA Marketplaces Expand Coverage for Chronically Ill
- Sex Differences Persist in Academic Rank for Neuro...
- Large Drop Seen in Infection-Related Post-Transpla...
- Preserved Neurogenesis in Hippocampus of Healthy S...
- Online Doc Reviews Don't Reflect Patient Satisfact...
- Enhanced Vascular Biocompatibility and Remodeling ...
- Editorial introductions
- Evolving criteria for the diagnosis of antibody-me...
- Novel oral anticoagulants in chronic kidney diseas...
- Changing concepts of HIV infection and renal disease
- Fluid status assessment in hemodialysis patients a...
- Apolipoprotein L1 nephropathies: 2017 in review
- An update on predicting renal progression in IgA n...
- Glomerulogenesis and the role of endothelium
- The association of proton pump inhibitors and chro...
- Evolving complexity of complement-related diseases...
- Advances in molecular diagnosis and therapeutics i...
- Halogens are key cofactors in building of collagen...
- Controversies in vascular access
- Gender differences in hypertension
- Fracture risk and treatment in chronic kidney disease
- Clinical and Endoscopic Remission in a Patient Wit...
- Actinomycotic Hepatic Abscess Mimicking Liver Tumor
- Localized Gastrointestinal ALλ Amyloidosis
- Diffuse Esophageal Squamous Papillomatosis Coverin...
- Validation of the Simplified Chinese Version of th...
- Formation of Chromatin Subcompartments by Phase Se...
- Chromatin Higher-Order Folding: A Perspective with...
- Gastric adenomas in familial adenomatous polyposis...
- Colorectal malakoplakia in a patient with hypogamm...
- Superficial esophageal squamous cell carcinoma res...
- Metastatic rhabdomyosarcoma mimicking autoimmune p...
- Gastric calcifying fibrous tumor mimicking GI stro...
- Theragnostic target, prostate-specific membrane an...
- Clinical outcomes for patients with Gleason Score ...
- Dosimetric evaluation of incorporating patient geo...
- Altered Long Non-Coding RNA Transcriptomic Profile...
- Micro-Dystrophin Gene Therapy Goes Systemic in Duc...
- CAR T Cells in Trials: Recent Achievements and Cha...
- p53 Plays a Key Role in the Apoptosis of Human Ova...
- Acrodermatitis-Like Rash in Kawasaki Disease
- Impact of Esophageal Atresia on the Success of Fun...
- The Left Ventricle in Congenital Diaphragmatic Her...
- Catheter-Related Venous Thrombosis in Hospitalized...
- Cannabis Use Tied to Increased Likelihood of Cigar...
- Composite Subretinal Implants May Lessen Vision Lo...
- Few Indoor Tanners Have Been Screened for Skin Cancer
- ADHD Frequently Co-Occurs with Autism Spectrum Dis...
- Coffee Consumption Cuts Coronary Artery Calcification
- Mood Disorders Up for Children of Consanguineous P...
- Lactation Lowers Risk of T2DM After Gestational Di...
- Smoking Status Associated With Poor Diet Quality
- mRNA Assay Less Sensitive Than DNA Assay for Laten...
- New Map Improves Emergency, Trauma Care Referrals
- A Closed-chest Model to Induce Transverse Aortic C...
- Measuring the Kinematics of Daily Living Movements...
- A Blood-based Test for the Detection of ROS1 and R...
- Initiating a Robotic Thyroidectomy Program in India
- An Integrated Platform for Genome-wide Mapping of ...
- Detergent-free Ultrafast Reconstitution of Membran...
- Effect of resource availability on evolution of vi...
- https://ift.tt/2Jk4Bcc
- Systematic review with meta‐analysis: association ...
- An Atypical Case of Bartonella henselae Osteomyeli...
- A CLK3-HMGA2 Alternative Splicing Axis Impacts Hum...
- To Be Young at Heart
- The Rules of Successful Speed Dating Are Complex, ...
- Building Bonds: Cancer Stem Cells Depend on Their ...
- Mentoring the Next Generation: Fiona Watt
- Reciprocal Signaling between Glioblastoma Stem Cel...
- Orchestrating Ribosomal Subunit Coordination to Co...
- De Novo DNA Methylation: Marking the Path from Ste...
- Human Pluripotent Stem Cell-Derived Endoderm for M...
- Coordinated Control of mRNA and rRNA Processing Co...
- Human Hippocampal Neurogenesis Persists throughout...
- Regenerative Rehabilitation: Applied Biophysics Me...
- Vascular Tissue Engineering: Progress, Challenges,...
- Sending Cancer into the Fetal Position
- Large-Scale Clonal Analysis Resolves Aging of the ...
- Chromatin Accessibility Dynamics during Chemical I...
- Comparison of plasma ctDNA and tissue/cytology-bas...
- Postoperative intra-abdominal infection is an inde...
- Recurrent non-functioning pituitary adenomas: a re...
- The effect of dose escalation for large squamous c...
- Prevalence of drug–drug interactions in geriatric ...
- Association of parental methylenetetrahydrofolate ...
- Hyperparasitaemia during clinical malaria episodes...
- Invasive Lobular Carcinoma of the Breast with Extr...
-
▼
Απρ 05
(179)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Πέμπτη 5 Απριλίου 2018
A CLK3-HMGA2 Alternative Splicing Axis Impacts Human Hematopoietic Stem Cell Molecular Identity throughout Development
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
https://ift.tt/2MQ8Ai8
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.