Diffuse Esophageal Squamous Papillomatosis Covering the Entire Esophagus

A 23-year-old woman presented to the clinic with complaints of heartburn and dysphagia with solid foods. Her family history was remarkable for gastric and lung cancer in first-degree relatives. Her physical examination and routine laboratory study results were normal. An upper endoscopy was performed and showed multiple polypoid lesions ranging in size from 3 to 11 mm, involving the entire esophagus (Figure A; Video). An endoscopic polypectomy of several of the larger polyps was performed. Histopathologic examination showed the lesions were squamous papillomas with areas of hyperkeratinization.

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