Abstract Purpose: To evaluate whether their combination was more effective than either alone in decreasing renal damage due to ischemia/reperfusion (I/R) injury in rats. Methods: Thirty-two Wistar rats were assigned to four groups. Following right nephrectomy, their left kidneys were subjected to warm ischemia (IR), cold ischemia (TH+IR), intraperitoneal injection of 10 mg/kg melatonin (MEL+IR), or injection of 10 mg/kg melatonin followed by cold ischemia (MEL+TH+IR). Eight randomly assigned right kidneys constituted the control group. After 240 min of reperfusion, left nephrectomy was performed for histopathological evaluation, lipid peroxidation, and measurement of antioxidant enzyme activity. Serum was collected to measure urea and creatinine concentrations. Results: Histopathological damage induced by ischemia and reperfusion was more attenuated in the MEL+TH+IR group than in the MEL+IR and TH+IR groups (p<0.037). Superoxide dismutase activity was significantly higher (p<0.029) and creatinine (p<0.001) and urea (p<0.001) concentrations were significantly lower in the MEL+TH+IR group than in the MEL+IR and TH+IR groups. Conclusion: The combination of melatonin (MEL) and topical hypothermia (TH) better protects against renal I/R injury than does MEL or TH alone.
https://ift.tt/2JE84CN
Αρχειοθήκη ιστολογίου
-
►
2023
(138)
- ► Φεβρουαρίου (74)
- ► Ιανουαρίου (64)
-
►
2022
(849)
- ► Δεκεμβρίου (61)
- ► Σεπτεμβρίου (74)
- ► Φεβρουαρίου (65)
-
►
2021
(2936)
- ► Δεκεμβρίου (59)
- ► Σεπτεμβρίου (180)
- ► Φεβρουαρίου (325)
-
►
2020
(1624)
- ► Δεκεμβρίου (293)
- ► Σεπτεμβρίου (234)
- ► Φεβρουαρίου (28)
-
►
2019
(13362)
- ► Δεκεμβρίου (19)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (5586)
- ► Ιανουαρίου (5696)
-
▼
2018
(66471)
- ► Δεκεμβρίου (5242)
- ► Σεπτεμβρίου (5478)
-
▼
Απριλίου
(5349)
-
▼
Απρ 12
(293)
- ER{alpha}-Mediated Nuclear Sequestration of RSK2 I...
- Cancer Research: Embracing the Complexity of Cance...
- Lessons from the Crypt: HMGA1—Amping up Wnt for St...
- Small-Molecule Activators of Protein Phosphatase 2...
- Silencing the Snail-Dependent RNA Splice Regulator...
- The Plausibility of the Obesity Paradox in Cancer—...
- HER2 Overexpression Triggers an IL1{alpha} Proinfl...
- The Importance of Body Composition in Explaining t...
- Evidence for an Overweight Paradox in Cancer: Insi...
- Germline Mutations in the Mitochondrial 2-Oxogluta...
- NRAS-Mutated Rhabdomyosarcoma Cells Are Vulnerable...
- CXCL12{gamma} Promotes Metastatic Castration-Resis...
- Tumorigenic and Antiproliferative Properties of th...
- Targeting Brain-Adaptive Cancer Stem Cells Prohibi...
- S-Nitrosylation of cIAP1 Switches Cancer Cell Fate...
- Fatal cervicomediastinal necrotising fasciitis due...
- Acute chylous peritonitis as a result of jejunal v...
- Hybrid Capture-Based Genomic Profiling of Circulat...
- Introducing a New Series: Immunotherapy Facts and ...
- Small-Cell Neuroendocrine Tumors: Cell State Trump...
- Ponatinib Shows Potent Antitumor Activity in Small...
- Harnessing the Power of Patient-Reported Outcomes ...
- Use of PRO Measures to Inform Tolerability in Onco...
- A Combination of SAHA and Quinacrine Is Effective ...
- Analysis of Drug Development Paradigms for Immune ...
- Drug Resistance in HER2-Positive Breast Cancer Bra...
- Long Noncoding RNA LINC01234 Functions as a Compet...
- Pembrolizumab Plus Pegylated Interferon alfa-2b or...
- Early Assessment of Lung Cancer Immunotherapy Resp...
- Phase I Study of Single-Agent Utomilumab (PF-05082...
- Nitric Oxide Production by Myeloid-Derived Suppres...
- Trainee Autonomy and Patient Safety
- Measuring Processes of Care in Palliative Surgery:...
- In the Next Issue
- To Cut is to Cure: The Surgeon's Role in Improving...
- Cause-specific Mortality in a Population-based Coh...
- ALPPS Improves Resectability Compared With Convent...
- Sequential ALK Inhibitors Can Select for Lorlatini...
- PDGF-A signaling is required for secondary alveola...
- Disrupting the three-dimensional regulatory topolo...
- Regulation and function of H3K36 di-methylation by...
- Conserved functional control, but distinct regulat...
- Xenopus ADAM19 regulates Wnt signaling and neural ...
- Polycomb group (PcG) proteins and Pax6 cooperate t...
- PUF-8 facilitates homologous chromosome pairing by...
- The heart tube forms and elongates through dynamic...
- In vivo imaging: shining a light on stem cells in ...
- The ontogeny, activation and function of the epica...
- Head formation requires Dishevelled degradation th...
- PDGF-A signaling is required for secondary alveola...
- The mir-279/996 cluster represses receptor tyrosin...
- Disrupting the three-dimensional regulatory topolo...
- Evolutionary divergence of the sex-determining gen...
- Evolutionarily conserved anterior expansion of the...
- L(3)mbt and the LINT complex safeguard cellular id...
- Polycomb group (PcG) proteins and Pax6 cooperate t...
- PUF-8 facilitates homologous chromosome pairing by...
- The heart tube forms and elongates through dynamic...
- Imprinted gene dysregulation in a Tet1 null mouse ...
- In vivo imaging: shining a light on stem cells in ...
- The ontogeny, activation and function of the epica...
- BRAF and MEK inhibitors increase PD1-positive mela...
- FDA Approval Summary: Niraparib for the maintenanc...
- Next-Generation Sequencing of the Complete Mitocho...
- Rare Presentation of Intraductal Papillary Neoplas...
- Pharmacists Can Help With DM Management Via Teleme...
- Recent Years Saw Increase in Burden of Prior Autho...
- Quality of Life Predicts Mortality in Older Breast...
- Negative Fateful Life Events Linked to Advanced Br...
- Many Providers Unaware of Racial Disparities in Ki...
- Correlation of listhesis on upright radiographs an...
- Mass cytometry: a powerful tool for dissecting the...
- Obesity induced T cell dysfunction and implication...
- The emerging role of immunotherapy in advanced uro...
- Editorial introductions
- Advances in prostate-specific membrane antigen PET...
- Recent advances in radiation oncology: multimodal ...
- Tobacco and alcohol-induced epigenetic changes in ...
- Managing seminomatous and nonseminomatous germ cel...
- The evolving genomic landscape in urothelial cancer
- False-Positive Uptake of 131I Due to Tubal Ligatio...
- Clinical Impact of Radioguided Localization in the...
- [44Sc]Sc-PSMA-617 Biodistribution and Dosimetry in...
- False-Positive Results in 18F-Fluorocholine PET/CT...
- Quality and Safety in Health Care, Part XXXIV: Cor...
- BSREM Reconstruction for Improved Detection of In-...
- Complete Metabolic Response of Advanced Melanoma t...
- Duodenum Cryptococcosis Mimicking Primary Duodenum...
- 99mTc-Methionine Hybrid SPECT/CT for Detection of ...
- FDG PET/CT Findings of Erdheim–Chester Disease: Ra...
- 18F-FDG PET/CT Equivalent of the Hepatic Hot Spot ...
- Metaplastic Squamous Cell Carcinoma of Breast Demo...
- Gastric Metastasis of Prostate Cancer as an Unusua...
- Adalimumab-Induced Epstein-Barr Virus–Related Lymp...
- Combined effects of melatonin and topical hypother...
- The role of oxymatrine in regulating TGF-β1 in rat...
- Preoperative subcutaneous sildenafil injection inc...
- Effect of varying hypoxia reoxygenation times on a...
- Muscle regeneration through therapy with estromal ...
- Effect of ozone oxidative preconditioning on infla...
-
▼
Απρ 12
(293)
- ► Φεβρουαρίου (4835)
- ► Ιανουαρίου (5592)
-
►
2017
(44259)
- ► Δεκεμβρίου (5110)
- ► Σεπτεμβρίου (5105)
-
►
2016
(7467)
- ► Δεκεμβρίου (514)
- ► Σεπτεμβρίου (1038)
- ► Φεβρουαρίου (793)
Αναζήτηση αυτού του ιστολογίου
Πέμπτη 12 Απριλίου 2018
Combined effects of melatonin and topical hypothermia on renal ischemia-reperfusion injury in rats
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
-
Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
-
heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
-
Alimentary Pharmacology &Therapeutics, EarlyView. https://ift.tt/2qECBIJ
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου
Σημείωση: Μόνο ένα μέλος αυτού του ιστολογίου μπορεί να αναρτήσει σχόλιο.