Partial Laryngeal IMRT for T2N0 Glottic Cancer: Impact of Image Guidance and Radiotherapy Intensification

This single institution study shows a high local control for partial laryngeal IMRT in T2 glottic cancer over a transition from IGRT matching surrogate from initial bone to laryngeal soft tissue, and further enhancement without increasing late toxicity when biological effective dose (α/β=10 Gy) was increased from 66.7 to 72 Gy using 2.0 Gy/fraction instead of 2.4 Gy/fraction. The results underline the importance of appropriate IGRT strategies and radiotherapy intensification using partial laryngeal IMRT.

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